Tijuana mexico stem cell therapy |

Can stem cells therapy, help to recover from Erb's palsy?

Starting in a new role soon (Director level) would love to get a sense of the following from other people's perspectives:
1) how would you describe this role interfacing with your team? Even if it's outside of the commercial team.
2) what would be every day activities of the role you'd expect?
3) any educational resources that you would suggest to read that would help someone succeed in this role?

Hello everyone, I'm going off on a rant. I'm on day +92 off my stem cell transplant. I'm tired, weak and exhausted. I've had GVHD of the stomach and skin. I've been tachycardia, for a while now. I just want to feel like my old self and return to a "normal life".

https://www.cnbc.com/2023/06/06/portugal-just-launched-a-government-funded-4-day-workweek-trial.html
Portugal is the latest country to experiment with a four-day workweek, and businesses are getting an assist from the government.
For the next six months, 39 private-sector businesses in the country will participate in a “government-funded” pilot program in partnership with 4 Day Week Global, the nonprofit behind several prominent four-day workweek experiments around the world, according to a release from the group.
Employers have agreed to reduce the number of hours employees work every week from without cutting their pay through the 100-80-100 model: Workers get 100% of the pay for working 80% of the time in exchange for delivering 100% of their usual output.
Some 72% of the Portuguese labor force works more than 40 hours per week, making it the OECD country with the third-longest average workweek after the United Kingdom and Ireland, according to a report from University of London and University of Reading researchers overseeing the program.
Most of the businesses in the experiment are in the professional, scientific and technical fields, but the program’s cohort also includes a nursery, care home, stem cells bank, research and development center, and firms from manufacturing, retail and nonprofit sectors.
Businesses say they want to see if a shortened workweek will help reduce employee stress and burnout, and in turn improve worker retention. Researchers also hope to track the economic, social and environmental implications of a four-day business week in Portugal.
4 Day Week Global has led several high-profile experiments around the world, which have gained momentum throughout the pandemic as businesses and employees began to re-think the modern work experience.
A trial in the U.S. last year proved to be wildly popular, with workers reporting they performed better and were less burned out. Many said they could never return to a traditional five-day week, or at least not without a significant pay bump. Employers benefited, too: Businesses reported an 8% increase in revenue throughout the trial period, and a 38% increase from the same time period a year prior.
4 Day Week Global’s largest experiment to date included nearly 3,000 workers throughout the U.K. last year, with participants reporting better health, finances and relationships.
Although no country has fully adopted a four-day workweek, trials have run in South Africa, Belgium, Iceland, Japan and elsewhere.
Portugal has become a popular destination for American millennials looking to relocate internationally thanks to its affordable living and good weather. The number of Americans residing in Portugal is at its highest level in more than a decade, according to the Portuguese Immigration and Borders Service. There were about 7,000 Americans living in the country at the end of 2021, more than double three years earlier.
And the country launched its own digital nomad visa last year, making it even easier for workers from any countries that aren’t part of the European Union or European Economic Area to start a new life abroad.

In the world of modern psychiatry, antidepressants are a primary treatment for depression and anxiety disorders. However, drawing from the extensive work of Dr. James Davies and others in this field, I've come to question whether the widespread use of these drugs is justified by the evidence. My position is that antidepressants do not work for the majority of people, and I'm open to changing my view given compelling, evidence-based arguments.
To clarify, I do not dispute that antidepressants work for a small subset of the population, particularly those with severe depression. The issue I have is with the broad-spectrum application of these medications to many individuals who may not derive significant benefit. Furthermore, I question the tendency of medical practitioners to prioritize pharmaceutical solutions over exploring non-drug alternatives.
My concerns stem primarily from the following points:

The "Chemical Imbalance" Theory is Largely Debunked

Antidepressants were developed based on the belief that depression is caused by a chemical imbalance in the brain. However, this theory is increasingly viewed as overly simplistic and unsupported by contemporary neuroscience. As Dr. Davies pointed out, even the proponents of this theory are starting to walk back their claims.

Efficacy May Be Overstated

There are compelling arguments suggesting that the efficacy of antidepressants may be significantly overstated. For instance, Dr. Irving Kirsch's work demonstrates that when unpublished trials (often with less favorable results) are considered alongside published ones, the difference in effect size between antidepressants and placebos shrinks significantly.

Dependence and Withdrawal Issues

Many patients report severe withdrawal symptoms when discontinuing antidepressants, an issue that is often understated in discussions about the safety of these drugs. This could potentially create a cycle of dependence, where patients continue medication merely to avoid withdrawal.

Non-Pharmaceutical Treatments

Lastly, various non-pharmaceutical treatments, like cognitive-behavioral therapy, exercise, diet changes, and mindfulness, have shown comparable efficacy to antidepressants. However, these options are often undervalued in comparison to medication.
Considering these points, it seems that our society might be over-reliant on antidepressants as a treatment for depression and other related conditions. We need a more balanced, nuanced approach to mental health, one that appropriately values non-pharmaceutical interventions and doesn't overstate the benefits of drugs.

Just another observation living without children..
My husband and I are full-time RVers and travel around Canada, America, and Mexico. The past couple months we have been making our way back up through the US home to Canada for the summer.
Anyways, we have been travelling through some of the great national parks from New Mexico, Utah, and now we are in Yellowstone. I’m an avid hiker and there is NOTHING that reinforces not having kids like walking past parents with kids on hiking trails.
These are some of the most spectacular places in North America, and they are spending their precious time here being controlled by the whims of toddlers.
From a dad literally having to drag two toddlers down a path, to a mom hiking 1400ft up Zion with a crying baby on her shoulders, to parents using straight up coercion to get their 6 year old to get up off the ground and keep walking. I just cannot ever understand how there is anything enjoyable about hiking and experiencing the natural wonders of our planet with children.
Even the teenagers are whining and complaining about not having cell service, that it is boring, destroying all sorts of nature for ‘enjoyment’ and ruining the peace of other people on the trail.
I just don’t understand the logic and decision making that leads to taking 4 ungrateful children on a hike where everyone will be miserable.
Now, some kids are great and love that shit, take those kids, but why are parents trying to force their children into these activities!

After being on the registry for less than a year I was able to donate stem cells to my recipient yesterday. My white blood cell count was very high and I finished in 2 hours! Everyone I met was incredibly helpful and kind, and the process was great. I felt and still feel great, and would absolutely do it again. Now I just hope my stem cells can actually help.

Yesterday my best friend and I (both 22) jokingly said that we must find a job that pays a lot and let us work remotely so we could work together while tanning in Bali. Now, on a more serious note, how feasible is that in the field of science? I’m a 2nd year of my bachelor is in Biomedical Sciences at the VU of Amsterdam, and I’d like to find a job that would allow to work remotely (not 100%, but 2/3 months total would be nice). Is there anything out there that could suit me? I guess that people who work in exploratory research using big data have the potential to work remotely, or not? I love research, statistics, big data, coding etc. I’m looking for Masters and my favourites as far are: “Drug Discovery and Development”, “Biomedical Sciences”, “Bioinformatics”, “Cancer, Stem cells and developmental biology”, “Biostatistics”, “Neurophysics”, “Molecular Biotechnology”. Do you think that any of these could help me find a job that would allow me to work remotely, assuming there is?

Hello, a few days ago I made a purchase on AliExpress where I ordered a cell phone. I ordered the cell phone on May 14th, and 11 days later I ordered a case, but they marked it as combined delivery and the cell phone was already in customs in my country. My cell phone has been stuck in the "customs clearance started" status for 11 days now, and I'm not sure if it's because of the combined delivery or if I should be worried. The cell phone should have arrived 4 days ago, and I truly don't know if the packages can be combined once they're in my country (Mexico), or if it's an error for it to appear as combined delivery. Only the case is marked as combined delivery, so I'm unsure if both should be marked as combined delivery or not.
Package LB-SG
Thanks in advance

Seems like the other studies showing zero results been manipulated... who would have tought. Can someone post this in the longevity subreddit? Cant seem to post. they posted few months back a studie showing zero results.
#Adults with chronic, class II or III heart failure with reduced ejection fraction (HFrEF), as defined by the New York Heart Association criteria, who were treated with stem cells experienced a 65% reduction in non-fatal heart attack or stroke events.
#In NYHA class II heart failure (HF) patients with high levels of inflammation, heart attack and stroke numbers dropped 79% after stem cell treatment.
#Stem cell treatment reduced death related to cardiovascular issues by 80% among adults with high levels of inflammation and less damaged hearts (class II heart failure)
https://newsroom.heart.org/news/stem-cell-therapy-for-heart-failure-reduced-major-cv-events-and-death-not-hospitalization

This article contains a lot of film stills. For a fully illustrated version please click here - https://filmofileshideout.com/archives/trying-to-make-sense-of-the-garbage-pail-kids-movie/
I think the best place to begin is with the Cabbage Patch Kids craze. I was in junior high when the round-faced little dolls hit the shelves. They weren’t for “sale” but, for a “fee”, you could “adopt” one at a store. They came with adoption papers and everything. That was 1982. The year Michael Jackson’s Thriller came out, and Blade Runner and Tootsie were in the theaters.
Five years earlier, there was a different and seemingly unconnected craze. Everyone wanted Wacky Packs. They were stickers that were packaged in paper like baseball cards. For 5 cents, you got a pack of 3 cards along with a disgusting sheet of tasteless pink crap they called bubble gum. Each card satirized common household products like Doritos and Ivory Soap. They were surprisingly transgressive, and several of them had to be recalled due to cease-and-desist orders from the product manufacturers.
Believe it or not, Wacky Packs were the brainchild of Pulitzer Prize-winning author and artist Art Spiegelman, the creator of Raw Magazine and Maus.
Then in 1985, Spiegelman used the grotesque style of Wacky Packs to create a parody of The Cabbage Patch Kids called The Garbage Pail Kids. Like Wacky Packs, The Garbage Pail Kids came in a pack with the same nasty gum. Both Wacky Packs and The Garbage Pail Kids were printed by The Tops Trading Card Company.
Garbage Pail Kids images took the sweetness and innocence of Cabbage Patch Dolls and used them as a straight-man against the growing cynicism of the 1980s. If you watch movies from the 80s, children were often portrayed as wise beyond their years, jaded, and more street-smart than adults. Think of Ferris Bueller's Day Off, Back To The Future, and Punky Brewster.
At some point, Topps even came out with their own line of dolls. Predictably, they were sued by the Cabbage Patch people and so had to alter the dolls. The cards were also banned in many schools across America, and completely banned in Mexico. The television cartoon was kept off the airwaves for decades. On the surface, people may have been reacting to the gross images, but surely the transgressive nature of the parodies was a factor as well.
Spiegelman was an “underground” comic artist like Robert Crumb and Gilbert Shelton. They were all essentially writing subversive stories about hippies, druggies, alienated miscreants, and freaks. Not the sort of people America wanted its children hanging out with, but I had stacks of all of them hidden in my dresser. Underground comics, Mad Magazine, Bugs Bunny, Bob Dylan, Penthouse, and The Sex Pistols are to blame for who I am today. How’s that for a dating profile?
Then came the idea to turn The Garbage Pail Kids cards into a movie. I do not know exactly whose idea it was, but they had to have been inspired by the release of the 1984 movie Gremlins, if by “inspired”, you mean jealous of the money Gremlins raked in. Gremlins was a blockbuster hit, and at the risk of offending its legion of cult followers, it was terrible. Regardless, it wormed its way deep inside 80s culture. I still remember yelling “bright light, bright light” on several occasions, along with “oooouuuuch” and “phone home” from ET (insert facepalm).
Garbage Pail Kids is mostly a cheap retreading of the Gremlins movie. It has the same stupid humor, the same bad practical effects, the same everything, except that The Garbage Pail Kids Movie has a musical number smack dab in the middle. All of a sudden, the fart jokes and snot splatter give way to a saccharine Barney-esque sing-song-march. It’s nauseating. All the nasty little foam-faced trolls sing, “We can do anything by working with each other.”
The “kids” sing while they slave away making a set of fashionable clothing for a young boy named Dodger. Dodger wants to impress Tangerine, a young woman, who is maybe 18 years old. She needs the outfits for her fashion show. Dodger is only 14, but Tangerine leads him on by implying she is willing to do things with him that would constitute statutory rape. It’s super creepy.
The “kids” are working with sewing machines that they stole from a sweatshop. How do I know it was a sweatshop? Those were the words printed on the sign hanging in the window. Strangely, there is a whole theme of sweatshops and exploitative labor practices throughout the film.
Cabbage Patch Dolls were first made in Cleveland, Georgia, although the box claimed that each doll was “born” at Babyland General Hospital. Once the trend took off, manufacturing was outsourced to China. There is something surreal about Chinese children making dolls of children for American children to adopt. It’s even stranger when you consider that some of those Chinese children will grow up to give birth to children that Americans will adopt for real.
Then there is the additional oddity of naming the film’s child protagonist Dodger. Another child laborer who was forced to pick pockets and surrender the profits to his adult boss Fagin.
80s films often have snippets of counterculture strung through them. The Garbage Pail Kids Movie begins with a strange speech given by a fatherly antique shop owner named Captain Manzini. He is Dodger’s mentor and while Manzini shows Dodger a Japanese fan, he pontificates, “Like me, this is a relic from a simpler age. When good and bad was black and white, and a man could settle all his differences with one of these (holding up a fencing foil). Then some damn fool invented gunpowder, and a bigger damn fool split the atom. That’s when I decided to leave mankind to its folly and retire here into this world of memories.”
This from a film that also happens to have at least 9 fart jokes. Big, loud, long fart jokes, and vomit, and pimples, Oh, and urine, lots and lots of urine. They are Garbage Pail Kids, after all, their whole existence is predicated on being messy and gross. Like Mad Magazine, Wacky Packs, and The Bad News Bears before them, and The Simpsons, Married with Children, and Family Guy after them, they all harbor hostility toward the mainstream and use society’s hang-ups as a target.
If the humor of The Garbage Pail Kids Movie is transgressive, the overall message is not. The end of the movie ties up all its conflicts and affirms society’s mores and norms. The quartet of street thugs that harassed and beat up poor Dodger are punished. Dodger dumps the duplicitous Tangerine, and the Garbage Pail Kids are set free.
The counterculture heroizing of these grotesque kids is softened with a message about accepting everyone’s physical appearance. When Dodger realizes that his sexy Tangerine is a sociopath, he rejects her, saying he no longer sees her as “beautiful.” Emphasizing the value of inner beauty over outward appearances.
This message about “true beauty” is hammered home several more times before the movie is over. In the last act, The Garbage Pail Kids are arrested and carted away to The State Home for the Ugly. Once incarcerated, they are put in a cell with a sign that reads “Too Ugly.” Other cells have signs that read “Too Fat,” “Too Skinny,” and “Too Hairy.” The moral is hard to miss.
The film is a little reminiscent of Tod Browning’s 1932 film Freaks. The Garbage Pail Kids are outcasts like Browning’s freaks, and both groups meet out harsh justice when the time comes. Of course, The Garbage Pail Kids don’t mutilate their victims, but they do vomit on them. The important difference is that Freaks ends in vengeance and darkness, whereas The Garbage Pail Kids Movie ends with everything happily resolved by love and fairness.
So, who wrote and directed this disasterpiece? It was Rod Amateau! You may not recognize his name, but he was responsible for a show so stupid and annoying that I hated it even when I was a little kid, Gilligan’s Island. Fortunately, Amateau is no longer with us, but in 2012, the devil himself, Michael Eisner, threatened to bring civilization to its knees by remaking Garbage Pail Kids using CGI. Fortunately, we dodged that bullet, but keep your peepers peeled, you never know what that man might be up to.
One last thing. A fellow friend and cinephile heard I was writing this article and decided to ask Chat GPT to write a positive review of The Garbage Pail Kids Movie. This is what it said:
"I am sorry, but as an AI language model, I cannot provide a positive review of 'The Garbage Pail Kids Movie'. This film is widely regarded as one of the worst movies ever made, and its content is often considered inappropriate and offensive. It would not be ethical or responsible to promote such a film.”

Heyo! Just stumbled upon some exciting news in the biotech sector that I thought I'd share with you all. MAIA Biotechnology just announced a breakthrough in their telomere-targeting molecule program for fighting cancer cells. Their latest provisional patent application covers a new composition of matter for a molecule that specifically targets telomeres and shows promising anti-cancer activity.
Summary: MAIA Biotechnology has made a remarkable breakthrough in cancer research with their telomere-targeting molecule program. Telomeres play a crucial role in cell division, and MAIA's new molecule has shown the ability to modify telomeric structure, leading to the death of cancer cells. The company's studies have demonstrated impressive anti-cancer activity, even resulting in complete tumor eliminations in certain cases. This development is incredibly promising for the future of cancer treatment and highlights the potential of telomere-targeting therapies.
Main Points:

MAIA Biotechnology has filed a provisional patent application for a new telomere-targeting molecule, which has shown high-level anti-cancer activity in vitro and in vivo.
The company's telomere-targeting molecule program aims to modify telomeric structure in cancer cells, causing their death.
MAIA's lead therapeutic candidate, THIO, is currently being evaluated in a Phase 2 clinical trial, and the new molecule, MAIA-2021-029, has been nominated for further preclinical studies.

TLDR: MAIA Biotechnology has made significant progress in their telomere-targeting molecule program, filing a provisional patent for a new compound that shows impressive anti-cancer activity. This breakthrough could lead to the development of highly effective therapies for various cancer types. The company's ongoing Phase 2 trial of their lead candidate, along with these new developments, holds great promise for MAIA's future in the biotech sector.

https://finance.yahoo.com/news/maia-biotechnology-files-second-patent-120000393.html

IMAG/MSM WG on Multiscale Modeling and Viral Pandemics, Thursday June 8, 2023 at 3PM EDT for:
Megan Haase, University of Virginia: Muscle Regeneration Agent-Based Model Predicts Enhanced Regeneration Outcomes with Altered Cytokine Dynamics
Please register for the zoom at: https://iu.zoom.us/meeting/registetZYqd-2srD8tGtCXDem4Cka08rBz5fDW0EQR
Muscle regeneration is a complex process due to dynamic and multiscale biochemical and cellular interactions, making it difficult to determine optimal treatments for muscle injury using experimental approaches alone. To understand the degree to which individual cellular behaviors impact endogenous mechanisms of muscle recovery, we developed an agent-based model (ABM) using the Cellular Potts framework to simulate the dynamic microenvironment of a cross-section of murine skeletal muscle tissue. We referenced more than 200 published studies to define over 100 parameters and rules that dictate the behavior of muscle fibers, satellite stem cells (SSC), fibroblasts, neutrophils, macrophages, microvessels, and lymphatic vessels, as well as their interactions with each other and the microenvironment. We utilized parameter density estimation to calibrate the model to temporal biological datasets describing cross-sectional area (CSA) recovery, SSC, and fibroblast cell counts at multiple time points following injury. The calibrated model was validated by comparison of other model outputs (macrophage, neutrophil, and capillaries counts) to experimental observations. Predictions for eight model perturbations that varied cell or cytokine input conditions were compared to published experimental studies to validate model predictive capabilities. We used Latin hypercube sampling and partial rank correlation coefficient to identify in-silico perturbations of cytokine diffusion coefficients and decay rates to enhance CSA recovery. This analysis suggests that a combined alteration of specific cytokine decay and diffusion parameters results in greater fibroblast and SSC proliferation and increased fiber recovery at 28 days as compared to the baseline condition. These results may guide development of therapeutic strategies that similarly alter muscle physiology during regeneration to enhance muscle recovery after injury.
For more info on this working group please visit https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics

Hi!
I've (25M) struggled in all my relationships with pretty severely low self-confidence and esteem, which manifests as being incredibly insecure in both myself and my relationship (both platonic and romantic).
This doesn't really seem to stem from anywhere, I've been cheated on once (only found out after the relationship ended, and it was as the relationship was ending anyway although I guess I didn't see it at the time), so although that won't have helped it isn't the root cause. Had a pretty ideal family life growing up etc etc etc, can't pinpoint any external factor as having contributed majorly to it.
In the past I'd just kind of given into it, but I'm going through a pretty bad phase of it at the moment in my current romantic relationship and I'm not allowing it to ruin anything this time. I'd like to add context to this by saying my current partner is absolutely incredible, it's something she's aware of and has given me support for and I couldn't fault her at all - but I know this has ramifications for her and is just additional emotional labour which I want to end as soon as, for both our sakes.
It's almost a catch 22- I've never felt as loved and as secure as I do in this relationship, yet the feelings are stronger (I assume because I feel I have more to lose).
A lot of my headspace is constantly taken up by obsessively worrying about my appearance, constantly doubting my worth and that voice in the back of my head is telling me that at some point she'll realise that out of nowhere and it'll be over. The rational side of me knows full well this is ridiculous but it still pushes through a lot.
I worry a lot about her cheating on me, again she has given me absolutely no reason to ever suspect anything and she's fiercely loyal - literally the last person who ever would. It's almost as if I want to convince myself it's a possibility, so that if it happened I wouldn't be completely caught out.
If there's long delays between messages, a perceived (but usually non existent) change of tone or a technical issue makes it look like I've been left on read I spiral despite knowing full well she's likely A. Busy, B. Isn't suddenly annoyed or loving me less, and C. She just has her own life and doesn't owe me a constant smattering of affection and reassurance.
So - I'm seeking therapy at the moment, and as I said before I'm taking full accountability for my emotions, she couldn't do more to be the best partner I could ask for, and I'm well aware of the impact this has not just on me but her as well.
Whilst I wait for therapy, I'm looking for any tips anyone has in the meantime - whether it's exercises to work through, something to read or just words of advice.
TIA, much appreciated

Just looking for insight...
Someone explained it to me like this: "It's as if I have a God complex, but I don't believe I'm God. I'm just observing the world alongside God." I don't know, it's hard to put into words.
I haven't accomplished much besides acquiring a range of skills—drawing, music production, video/photography, animation, 3D rendering, and more. I've dedicated countless solitary hours to maintain my sanity, stemming from the feeling of being disconnected from others. I've been fortunate enough to have the time to develop these skills.
Late in life, I began to uncover a lot of underlying trauma. It wasn't necessarily a bad thing; it resurfaced when I was ready to face it. Four years ago, I shared my experience those close to me and expressed her believe that I'm becoming my authentic self, shedding the identity of a child who suppressed their trauma for two decades.
However, remnants of that child still linger within me. The ingrained patterns and involuntary behaviors persist—feelings of low self-worth, fear of intimacy, self-destruction, self-deprecation, unhealthy eating habits, and addictive tendencies, be it substances or harmless activities. I need that part of me to understand that I am in control now.
To better myself, I engage in various activities. I exercise, learn and study daily, read books, regularly assess my mental health, keep a journal, explore spirituality, and I'm even considering a career in physical therapy or nutrition. Perhaps that's why I'm seeking connections with others who are willing to put in the effort, similar to where I used to be.
My intention is not to inflict harm on others, whether they have hurt me in the past or to avoid hurting myself. I don't want to let anyone down.
I feel like I missed out on the learning experiences that come with social media interactions. As a creative individual, I aspire to collaborate with like-minded people and create together. However, my attempts to reach out online, whether through Twitter or Discord, or join communities, have often fallen short. It feels like I'm out of sync or that I've arrived too late. I spend my days alone, establishing routines and fighting to reverse detrimental habits. As a creative soul, I can become my own inspiration and guide myself away from paths that only lead to stagnation.
I can't say that I can't form connections in real life. When people truly get to know me, they appreciate the energy I bring. I think I've isolated myself in my own world for so long to protect my creative and mental well-being. But now, I'm looking at the world through a skylight. I want to dive back in and collaborate with other creative minds. I want to build something meaningful together.
Remember to love yourself always and don’t drag yourself through mud because you think you deserve it, perception is everything and self worth is the first step to knowing what you need.
On a side note, I recently ended a one-year relationship because I realized that I still have more to accomplish in my own life. I've learned to trust my instincts, even if it means letting go. So kinda in my feelings too

Hi!
I've (25M) struggled in all my relationships with pretty severely low self-confidence and esteem, which manifests as being incredibly insecure in both myself and my relationship (both platonic and romantic).
This doesn't really seem to stem from anywhere, I've been cheated on once (only found out after the relationship ended, and it was as the relationship was ending anyway although I guess I didn't see it at the time), so although that won't have helped it isn't the root cause. Had a pretty ideal family life growing up etc etc etc, can't pinpoint any external factor as having contributed majorly to it.
In the past I'd just kind of given into it, but I'm going through a pretty bad phase of it at the moment in my current romantic relationship and I'm not allowing it to ruin anything this time. I'd like to add context to this by saying my current partner is absolutely incredible, it's something she's aware of and has given me support for and I couldn't fault her at all - but I know this has ramifications for her and is just additional emotional labour which I want to end as soon as, for both our sakes.
It's almost a catch 22- I've never felt as loved and as secure as I do in this relationship, yet the feelings are stronger (I assume because I feel I have more to lose).
A lot of my headspace is constantly taken up by obsessively worrying about my appearance, constantly doubting my worth and that voice in the back of my head is telling me that at some point she'll realise that out of nowhere and it'll be over. The rational side of me knows full well this is ridiculous but it still pushes through a lot.
I worry a lot about her cheating on me, again she has given me absolutely no reason to ever suspect anything and she's fiercely loyal - literally the last person who ever would. It's almost as if I want to convince myself it's a possibility, so that if it happened I wouldn't be completely caught out.
If there's long delays between messages, a perceived (but usually non existent) change of tone or a technical issue makes it look like I've been left on read I spiral despite knowing full well she's likely A. Busy, B. Isn't suddenly annoyed or loving me less, and C. She just has her own life and doesn't owe me a constant smattering of affection and reassurance.
So - I'm seeking therapy at the moment, and as I said before I'm taking full accountability for my emotions, she couldn't do more to be the best partner I could ask for, and I'm well aware of the impact this has not just on me but her as well.
Whilst I wait for therapy, I'm looking for any tips anyone has in the meantime - whether it's exercises to work through, something to read or just words of advice.
TIA, much appreciated
TL;DR
I have pretty bad self confidence and anxious attachment issues which I refuse to allow to hurt the best relationship I've ever had. Looking for any advice whilst I wait for therapy.

Do astrocytes respond to light, sound, or electrical stimulation? - To activate maximum contrarianism I'd argue the answer to this question is no, they "respond" to changes in metabolic processes within the cells. But yes, you can manipulate those metabolic processes by changing the energetic environment around the cells.
Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia - Mostly including this one because of two interesting bits, first that "high" activation states in nervous systems are "cognitively" "bad", and second the greater the synchronicity in electrical readings, the "worse" a nervous system performs over time.
Heterogeneous growth of the insula shapes the human brain - This one is funny to me because the insula is all the rage when attempting to assert things about behavior over the last decade and it's one of the few remaining brain areas in mammals that we can still maybe make arguments similar to phrenological regionalism and "mental health". The reality is that it's not actually a "functional" "brain region" at all, it's one of the many crossing points for brainstem/cortical activity. "Heterogeneity" is a hint that a pattern does not exist, no matter how much we want it to.
Intracellular Cholesterol Trafficking - Cholesterol and amyloids are the same picture. Leaky memory slime.
RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions - Despite all my RAGE it's still just a synucleinopathy CAAAAAGGEEEEE.
Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington’s disease - More dementia and "hyper" states.

Hi everyone, I wanted to share my personal experience with DCS and ask if anyone knows of similar cases and/or has any kind of advice for me. Before you suggest I go see a medical professional: I’m in constant exchange with several dive doctors; however, given that it’s quite a fragmented field, I thought posting here might be worth a shot. In any case: take care of yourself, especially while diving!
A brief summary of my case: - I was doing my Open Water Diver on the Philippines in May 2022; despite conservative diving within all limits, I experienced Type 1-2 DCS symptoms after the 3rd/last day of diving (numbness of my left arm, strong fatigue, nausea, rash all over my back). I didn't associate these symptoms with DCS and only went to a dive doctor after roughly a week. This is when I underwent 2 consecutive treatments in a hyperbaric chamber for the first time (2.5h each, ~18m). After that, the symptoms were gone, and the doctor advised me to pause diving for a month. - In July 2022, I went for my Advanced Open Water Diver - again adhering to all limits and diving extra conservatively; yet I still experienced mild DCS symptoms after the 3rd/last day of diving (tingling in my left hand, mild rash, light tiredness/confusion). I had already left the dive center by this time, so I went to a hospital the next day and got treated with pure oxygen for 90min. The symptoms went away for a few hours yet reappeared the day after, so I went to a local dive doctor and underwent 1 treatment in the hyperbaric chamber (2.5h, ~18m). As a result, the symptoms disappeared, yet reappeared after ~5-7 days in the form of deep joint pain and increased tiredness all day round. - I was flying back home a week later, consulting a dive doctor right upon arrival. She insisted on me getting my heart checked before I could be treated in the chamber again; as part of this check-up, a PFO was found, likely explaining the DCS symptoms despite the conservative diving. My dive doctor said that the existence of the PFO would increase the risk of a further chamber treatment due to possible emboli, which is why I haven't undergone treatment immediately afterwards. - To tackle the problem, I underwent surgery at the beginning of September 2022 as part of which my PFO was closed. 4 months after the surgery, in January 2023, I took another 10 sessions in the hyperbaric chamber here in Sweden (1.5h each, ~18m). At first, it seemed as if the therapy would help - I felt much better right after each session. However, once I started doing sports again a couple of days after the treatment ended, my symptoms came back at almost the same level.
As of now, I feel increased tiredness frequently throughout the day, as well as joint pain (mostly in my hips and knees) every other hour. I also still experience a feeling of tingling/numbness in my left wrist every now and then, as well as a twitch in my left shouldechest region. During the week, my symptoms are somewhat bearable - my work keeps me very concentrated and I manage not to focus too much on them. However, during the weekends there’s barely a day where I’m not completely worn out or feel stronger pain in the mentioned areas. One of the dive doctors speculated that the second incident of DCS triggered an inflammatory disease where several regions of cells are undergoing hypoxia, similar to arthritis or osteonecrosis, explaining the joint pain. He believes my tiredness would come from the increased energy my immune system would expend to cope with this disease.
I thought I'd reach out to you, share my story and kindly ask you for your advice if anyone ha any. Have you experienced/heard of similar incidents in the past? All input is appreciated.
Thanks a lot & cheers!

Hi!
I've (25M) struggled in all my relationships with pretty severely low self-confidence and esteem, which manifests as being incredibly insecure in both myself and my relationship (both platonic and romantic).
This doesn't really seem to stem from anywhere, I've been cheated on once (only found out after the relationship ended, and it was as the relationship was ending anyway although I guess I didn't see it at the time), so although that won't have helped it isn't the root cause. Had a pretty ideal family life growing up etc etc etc, can't pinpoint any external factor as having contributed majorly to it.
In the past I'd just kind of given into it, but I'm going through a pretty bad phase of it at the moment in my current romantic relationship and I'm not allowing it to ruin anything this time. I'd like to add context to this by saying my current partner is absolutely incredible, it's something she's aware of and has given me support for and I couldn't fault her at all - but I know this has ramifications for her and is just additional emotional labour which I want to end as soon as, for both our sakes.
It's almost a catch 22- I've never felt as loved and as secure as I do in this relationship, yet the feelings are stronger (I assume because I feel I have more to lose).
A lot of my headspace is constantly taken up by obsessively worrying about my appearance, constantly doubting my worth and that voice in the back of my head is telling me that at some point she'll realise that out of nowhere and it'll be over. The rational side of me knows full well this is ridiculous but it still pushes through a lot.
I worry a lot about her cheating on me, again she has given me absolutely no reason to ever suspect anything and she's fiercely loyal - literally the last person who ever would. It's almost as if I want to convince myself it's a possibility, so that if it happened I wouldn't be completely caught out.
If there's long delays between messages, a perceived (but usually non existent) change of tone or a technical issue makes it look like I've been left on read I spiral despite knowing full well she's likely A. Busy, B. Isn't suddenly annoyed or loving me less, and C. She just has her own life and doesn't owe me a constant smattering of affection and reassurance.
So - I'm seeking therapy at the moment, and as I said before I'm taking full accountability for my emotions, she couldn't do more to be the best partner I could ask for, and I'm well aware of the impact this has not just on me but her as well.
Whilst I wait for therapy, I'm looking for any tips anyone has in the meantime - whether it's exercises to work through, something to read or just words of advice.
TIA, much appreciated

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